Introduction
Sceletium tortuosum, also known as Sceletium or Kanna, is a remarkable plant with a rich history and a promising future. Traditionally used by indigenous people in South Africa, it has gained attention in modern science for its potential benefits in mental health, mood regulation, and overall well-being. This timeline explores the significant milestones in Sceletium research and highlights its role in Serobrine, a product designed to harness these benefits.
Timeline and References for Sceletium tortuosum Research
1996: Sceletium emerged as a promising natural remedy with remarkable pharmacological properties that warrant further exploration.
2008: The alkaloid mesembrine, which acts as a serotonin reuptake inhibitor, was isolated from Sceletium tortuosum. This finding suggests that Sceletium tortuosum, commonly known as Sceletium or Kanna, may have potential benefits in the context of mental health, particularly in relation to serotonin regulation.
2011: The potential benefits of Sceletium tortuosum are primarily attributed to its alkaloids, particularly mesembrine and mesembrenone. These alkaloids have shown strong effects on the 5-HT transporter, which is involved in serotonin signalling in the brain, and the PDE4 enzyme. Additionally, it has been demonstrated that Sceletium tortuosum and its alkaloids do not cause harm to cells.
2012: The alkaloids in Sceletium Tortuosum can be effective when taken orally because it is able to be absorbed through mucosal tissues.
2014: Found that Sceletium tortuosum holds potential as a natural remedy with positive effects on pain relief and mood regulation with a low risk of addiction. The results support the safe use of standardized Sceletium tortuosum extract in food and dietary supplements.
2015: The study contributes to the understanding of Sceletium metabolism and provides insights that can aid in monitoring the consumption of Sceletium as a supplement, ensuring its safe and responsible use in the context of dietary supplementation.
2016: Two studies were done in January. The first study suggests potentially beneficial effects of Sceletium extract rich in mesembrine for stress and hypertension. The second study confirms that Sceletium acts as an SSRI, but more as a monoamine-releasing agent which plays an essential role in regulating mood, emotions and other physiological functions.
2018: Sceletium alkaloids, Mesembrenol and Mesembranol have the potential to be used as starting points for developing new drugs to treat epilepsy and Sceletium tortuosum extracts have the potential to be employed as preventative supplements or complementary treatments for obesity and diabetes.
2022 (February): Sceletium extract, 50mg had similar effects to 5mg of a common anti-depressant in rats with depression-like behaviors.
2022 (April): Review concludes that existing studies show promising results for Sceletium tortuosum's ability to improve cognitive function (such as memory and thinking skills) and help manage anxiety and depression.
2022 (May): The study provides evidence for Sceletium's traditional and modern-day use as an anxiolytic.
2022 (August): The latest study suggests that Sceletium holds significant potential as a natural source for developing new compounds aimed at treating neurodegenerative disorders.
Conclusion
Sceletium tortuosum has a rich history and a scientifically supported potential in mental health and wellness. Serobrine leverages this ancient plant's benefits, offering a natural solution for those seeking to improve their mental well-being. As research continues to unfold, Sceletium tortuosum's role in modern health supplements like Serobrine is becoming increasingly clear, providing a bridge between traditional wisdom and contemporary science.

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References
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