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Benefits of Kanna (Sceletium Tortuosum): A Scientific Timeline

Updated: Sep 26, 2023

Benefits of Sceletium Based on Studies

Sceletium tortuosum, also known as Kanna, is a succulent plant native to South Africa. With a long history of traditional use by the San and Khoikhoi people, who used it to elevate mood, relieve anxiety, regulate sleep and quench thirst and exciting recent studies validating its use.

In 1738, Peter Kolbe, a keen botanist made this remark about Kanna (Sceletium)

“the greatest cheerer of the spirits and the noblest restorative in the world”

We are exploring the potential benefits discovered and linked to Sceletium in chronological order.

Illustration of the synergy between ingredients and their benefits

What are the scientific benefits Kanna (Sceletium tortuosum) can offer?

Sceletium tortuosum, also known as Sceletium or Kanna, has traditionally been used for its mood-enhancing properties. It has a long history of promoting well-being, relaxation and a positive outlook. Over the years it has gained recognition for its remarkable benefits in promoting mental health and overall well-being. Its alkaloids, particularly mesembrine and mesembrenone, play a key role in regulating serotonin levels and promoting emotional balance.

Numerous studies have shown the positive effects of Sceletium in managing stress, anxiety, and depression by acting as a natural selective serotonin reuptake inhibitor (SSRI). It has also been found to enhance cognitive function, including memory and thinking skills, leading to improved cognitive performance and mental clarity.

In addition to its mental health benefits, Sceletium shows promise in alleviating pain and has potential applications in the treatment of epilepsy. It may also serve as a preventative supplement for obesity and diabetes.

Recent studies have highlighted the significant potential of Sceletium in developing new compounds for the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. This underscores its growing importance in the field of neuroscience and its potential to improve the lives of those affected by these conditions.

Overall, Sceletium holds great promise as a natural supplement for improving mental health and overall well-being. Its positive effects on serotonin regulation, cognitive function, pain management, and potential applications in treating neurodegenerative disorders make it a valuable option for individuals seeking natural approaches to enhance their quality of life.

Sceletium Tortuosum (Kanna) Scientific Timeline

Why Serobrine is the preferred Sceletium supplement


Sceletium Tortuosum (Kanna) Scientific Timeline

1996: Sceletium emerged as a promising natural remedy with remarkable pharmacological properties that warrant further exploration.

2008: The alkaloid mesembrine, which acts as a serotonin reuptake inhibitor, was isolated from Sceletium tortuosum. This finding suggests that Sceletium tortuosum, commonly known as Sceletium or Kanna, may have potential benefits in the context of mental health, particularly in relation to serotonin regulation.

2011: The potential benefits of Sceletium tortuosum are primarily attributed to its alkaloids, particularly mesembrine and mesembrenone. These alkaloids have shown strong effects on the 5-HT transporter, which is involved in serotonin signalling in the brain, and the PDE4 enzyme. Additionally, it has been demonstrated that Sceletium tortuosum and its alkaloids do not cause harm to cells.

2012: The alkaloids in Sceletium Tortuosum can be effective when taken orally because it is able to be absorbed through mucosal tissues.

2014: Found that Sceletium tortuosum holds potential as a natural remedy with positive effects on pain relief and mood regulation with a low risk of addiction. The results support the safe use of standardized Sceletium tortuosum extract in food and dietary supplements.

2015: The study contributes to the understanding of Sceletium metabolism and provides insights that can aid in monitoring the consumption of Sceletium as a supplement, ensuring its safe and responsible use in the context of dietary supplementation.

2016: Two studies were done in January. The first study suggests potentially beneficial effects of Sceletium extract rich in mesembrine for stress and hypertension. The second study confirms that Sceletium acts as an SSRI, but more as a monoamine-releasing agent which plays an essential role in regulating mood, emotions and other physiological functions.

2018: Sceletium alkaloids, Mesembrenol and Mesembranol have the potential to be used as starting points for developing new drugs to treat epilepsy and Sceletium tortuosum extracts have the potential to be employed as preventative supplements or complementary treatments for obesity and diabetes.

2022: In February Sceletium extract, 50mg had similar effects to 5mg of a common anti-depressant in rats with depression-like behaviors.

2022: In April review concludes that existing studies show promising results for Sceletium tortuosum's ability to improve cognitive function (such as memory and thinking skills) and help manage anxiety and depression.

2022: The study in May provides evidence for Sceletiums traditional and modern-day use as an anxiolytic.

2022: The latest study done in August suggests that Sceletium holds significant potential as a natural source for developing new compounds aimed at treating neurodegenerative disorders.

Why Serobrine is the preferred Sceletium supplement

  • We use an extract of the natural active ingredients to standardize our product and deliver consistent results.

  • Our product contains NAD+, a coenzyme found in every cell of the body, re-energizing cell metabolism and optimizing body and brain functionality.

  • The addition of Vit B6 completes the synergy by rebuilding serotonin and dopamine stores in the brain, whilst assisting with good sleep.

  • We are SAHPRA registered.

Serobrine is not just another supplement; it's a catalyst for personal and professional growth. By harnessing the power of natural ingredients and scientific research, Serobrine offers a comprehensive solution to enhance your performance, boost focus, and improve overall well-being. Join the Serobrine community and unlock your true potential today!

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